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Anti-Estrogen Powder CAS 302-22-7 Chlormadinone Acetate with fast delivery and
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CAS:302-22-7
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Wuhan Hezhong Biochemical Manufacturing Co., Ltd.2020-07-10 09:46:19
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Product Details
Appearance: | White Crystalline Powder | Storage: | Cool And Dry Place | Assay: | Above 99% |
Delivery: | TNT,DHL,Fedex,EMS,HKEMS,UPS,etc | Shipping Method: | Air&Sea Transporation,Express | Product Name: | Chlormadinone Acetate |
Product Description
Anti-Estrogen Powder 302-22-7 Chlormadinone Acetate
Quick Detail
Chlormadinone acetate
Product name: Chlormadinone acetate
CAS Registry Number: 302-22-7
Assay: 98%
Molecular Formula: C23H29ClO4
Molecular weight: 404.93
Reference Standard: CP
Appearance: White or slightly yellow crystalline powder
Description:
(1)Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999.
(2)Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT).
(3)In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.
(4)The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.
(5)Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.
(6)The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions.
Applications:
Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties.
CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production.
CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.
Specifications:
COA :
TEST ITEMS |
SPECIFICATION |
RESULTS |
Description |
White or Almost White Crystalline Powder |
white powder |
Identification |
: A.B. |
Positive |
Assay |
: 97.0~102.0% |
99.3% |
Specific Rotation |
: +101°~+105° |
+102.6° |
Loss On Drying |
: 1.0%max |
0.27% |
Melting Point |
: 153~157°C |
153.0~155.0°C |
Organic Volatile Impurities |
: meets the requirement. |
Conforms |
Related Substances |
: meets the requirement. |
Conforms |
Residual Solvents |
: meets the requirement. |
Conforms |
Particle Size |
: 100% ≤ 20 microns |
Conforms |
Conclusion |
The specification conform with USP30 standard |
Our Service:
1.Fast Delivery:We can delivery within 24 hours upon receipt of your payment.
2.Quality can be promised.Hot sell to Worldwide.
3.Payment Terms:T/T,BITCOIN,MoneyGram,WESTERN UNION,Paypal Available.
4.Free Sample available at any time.
5.Tracking your order at any time.Inform your orders further new situation at any time.
6.Package:Professional packing with professional materials.
Our advantage:
1.We have experience in exporting steroids, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;
2.Quality:Our company is a professional leading factory in China in pharmaceutical area, We had stable customers and exported to Germany, Spain, UK, USA, Australia, Middle East, and any other countries.We can provide good references about our company.As for the quality of the products, we e sure they can satisfy you well enough;
3.Package:Professional packing with professional materials
4.Delivery:We have products in stock, and we will deliver them soon when your PO arrived.Meanwhile we will give you the tracking number in order to make you know the exact location of the products.We will keep track of the product until they arrive you;We choose the best courier service for you, and with the delivery around 5-7 working days.
5.Service:Best Service with after-sales service and consultation
The main Product list
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2 | Testosterone phenylpropionate | CAS: 1255-49-8 |
3 | CAS :58-22-0 | |
4 | Testosaterone decanoate | CAS:5721-91-5 |
5 | Testosterone cypionate | CAS:58-20-8 |
6 | Testosterone isocaproate | CAS:15262-86-9 |
7 | Testosterone enanthate | CAS:315-37-7 |
8 | Testosterone Undecanoate | CAS:5949-44-0 |
9 | Testosterone propionate | CAS:57-85-2 |
10 | CAS:434-22-0 | |
11 | Nandrolone Phenylpropionate | CAS:62-90-8 |
12 | Nandrolone Decanoate | CAS:360-70-3 |
13 | Trenbolone acetate | CAS:10161-34-9 |
14 | Trenbolone Hexahydrobenzyl Carbonate | CAS:23454-33-3 |
15 | Trenbolone enanthate | CAS:472-61-546 |
16 | Methenolone acetate | CAS:434-05-9 |
17 | Methenolone enanthate | CAS:303-42-4 |
18 | Articaine hydrochloride | CAS:23964-57-0 |
19 | Procaine hydrochloride | CAS:51-05-8 |
20 | Lidocaine Hydrochloride | CAS:73-78-9 |
21 | Propitocaine hydrochloride | CAS:1786-81-8 |
22 | Tetracaine hydrochloride | CAS:136-47-0 |
23 | Tamoxifen citrate | CAS: 54965-24-1 |
24 | Boldenone Acetate | CAS:2363-59-9 |
25 | Boldenone Cypionate | CAS:106505-90-2 |
26 | Boldenone Undecylenate | CAS: 13103-34-9 |
27 | CAS:846-48-0 | |
28 | Drostanolone Propionate | CAS: 521-12-0 |
29 | Drostanolone Enanthate | CAS:472-61-145 |
30 | CAS :2446-23-3 | |
31 | Sustanon 250 | |
32 | CAS:10418-03-8 | |
34 | Methyltrienolone | CAS: 965-93-5 |
35 | CAS: 1424-00-6 | |
36 | CAS : 58-18-4 | |
37 | Methandrostenolone | CAS:72-63-9 |
38 | Mebolazine | CAS:3625-07-8 |
39 | Medroxyprogesterone 17-acetate | CAS:71-58-9 |
40 | Methyltrienolone | CAS:965-93-5 |
41 | Diethylstilbestrol | CAS: 6898-97-1 |
42 | Dapoxetine | CAS:119356-77-3 |
43 | Drospirenone | CAS:67392-87-4 |
44 | CAS:17230-88-5 | |
45 | Dienogestrel | CAS:65928-58-7 |
46 | Nilestriol | CAS: 39791-20-3 |
47 | Nonoxynol | CAS:26027-38-3 |
48 | Estradiol valerate | CAS: 979-32-8 |
49 | Estradiol enanthate | CAS: 4956-37-0 |
50 | Ethisterone | CAS:434-03-7 |
51 | Ecdysone | CAS:3604-87-3 |
52 | Altrenogest | CAS:850-52-2 |
53 | CAS:645-05-6 | |
54 | Acetildenafil | CAS:831217-01-7 |
55 | CAS: 112809-51-5 | |
56 | Trilostane | CAS:13647-35-3 |
57 | CAS: 5630-53-5 | |
58 | Levonorgestrel | CAS:797-63-7 |
59 | Levobupivacaine hydrochloride | CAS:27262-48-2 |
60 | CAS:434-07-1 | |
61 | CAS:53-39-4 | |
62 | CAS:1239-29-8 | |
63 | CAS:76-43-7 | |
64 | Genistein | CAS:446-72-0 |
65 | CAS:52-01-7 | |
66 | Ropivacaine mesylate | CAS:854056-07-8 |
67 | CAS:171596-29-5 | |
68 | Benzocaine | CAS:94-09-7 |
69 | Yohimbine hydrochloride | CAS:65-19-0 |
70 | Lidocaine base | CAS:137-58-6 |
71 | CAS:224785-91-5 | |
72 | 19-Norethindrone acetate | CAS:51-98-9 |
73 | Hydroxyprogesterone Caproate | CAS:630-56-8 |
74 | Pregnenolone | CAS:145-13-1 |
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