No Side Effects Orlistat for Weight Loss Steroids Orlipastat USP Standard

No Side Effects Orlistat for Weight Loss Steroids Orlipastat USP Standard Orlistat Powders CAS 96829-58-2

1.Orlistat Basic Information

Product Name	Orlistat
Alias	Orlipastat
CAS	96829-58-2
Assay	99.0%
Appearance	White Powder
Molecular Formula	C29H53NO5
Molecular Weight	495.73
Grade	Pharmaceutical Grade
Storage	Shading, Confined Preservation
Brand Name	NJBN STEROID

2.Orlistat Introduciton

Orlistat blocks some of the fat which you eat, keeping it from being absorbed because of your body. Orlistat is used to aid in weight reduction, or to lessen the risk of regaining weight lost.

This medicine is employed together with a reduced-calorie diet. Orlistat is good for use only in grown-ups. Orlistat (prescription and nonprescription) is utilized with an individualized low-calorie, low-fat eating and working out program to help lose weight. Prescription orlistat is used in overweight people who can also have high blood pressure, diabetes, high-cholesterol, or coronary disease.

Orlistat is also used after weight-loss to help keep from gaining back that weight. Orlistat is within a class of medications called lipase inhibitors. It functions by preventing a number of the fat in foods eaten from being absorbed from the intestines. This unabsorbed fat will be removed from our bodies in the stool.

Orlistat is currently internationally recognized as a new type of weight loss lipid-lowering drugs with the marketed product being under the name of Xenical. It was first listed in New Zealand in 1998 with annual sale of $ 146 million at that time. In 2007, the sale reaches $ 538 million, Orlistat occupy 80% of the market share of the global weight-loss market with the annual sale of only China Hong Kong year reaching 80 million US dollars.

Orlistat is a long-acting and potent specific inhibitor of gastrointestinal tract lipase, appearing as white or white-like powder at room temperature and being insoluble in water, soluble in chloroform and easily soluble in ethanol. It can form covalent bonds with the active serine sites of the gastric lipase and the pancreatic lipase in the stomach and small intestine cavity, resulting in inactivation of the enzymes. Fat in food can’t be broken down into free fatty acids and monoacylglycerols so that the fat can’t be absorbed and utilized, thereby having reduced the bodys calorie intake to control the body weight.

The drug does not need to be absorbed through the body. At normal doses, the absorption of fat can be inhibited by 30%. There is little absorption after oral administration. It can be subject to metabolic inactivation in the intestine with the metabolic sites located in the gastrointestinal wall. The elimination half-life is about 14 to 19 hours. About 97% of the goods are excreted with the feces, of which 83% are in the prototype.

Clinically orlistat can be applied to the treatment of obesity and hyperlipidemia. Under normal circumstances, it can be subject to oral administration at a dose of 120 mg for three times per day. Take it during the meal or 1 hour after a meal. After 2 weeks of administration, the body weight can begin to decline. It can be taken continuously for 6 to 12 months. If the dose is increased to above 400 mg daily, the effect will no longer be further enhanced.

Fat Loss Mechanism

Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body. Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool.

This medication is used along with a doctor-approved reduced-calorie diet, exercise, and behavior modification program to help significantly overweight (obese) persons lose weight. Taking orlistat can also help prevent you from regaining the weight you have lost. Losing weight and keeping it off can reduce the many health risks that obesity causes, including heart disease, diabetes, high blood pressure, some forms of cancer, certain breathing problems, and a shorter life span.

Dietary fats need to be broken down into smaller pieces before the body can absorb them. Orlistat works by blocking the enzyme that breaks down fats in your diet. This undigested fat then passes out of your body in your bowel movement. Orlistat does not block the absorption of calories from sugar and other non-fat foods, so you still need to restrict your total intake of calories.

3.Orlistat Applications:

1 .	Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body
2 .	Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool.
3 .	Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug
4 .	Dietary fats need to be broken down into smaller pieces before the body can absorb them. Orlistat works by blocking the enzyme that breaks down fats in your diet. This undigested fat then passes out of your body in your bowel movement
5 .	Orlistat does not block the absorption of calories from sugar and other non-fat foods, so you still need to restrict your total intake of calories
6 .	Orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). In the United States and the European Union, orlistat is available for sale without a prescription. Generic formulations of orlistat are available in some countrie

4.Orlistat Dosage

Orlistat is usually taken 3 times a day during every meal containing fat. The average dosage is a 120mg per day. Due to the fact that Xenical may decrease the absorption of vitamins and it is useful to take a multivitamin once a day at bedtime. While taking this drug bodybuilders and athletes should follow their diet, medication, and exercise routines very closely.

No Side Effects Orlistat for Weight Loss Steroids Orlipastat USP Standard Orlistat Powders CAS 96829-58-2

5.Orlistat COA

Items	Specification Items
Appearance	white or almost white crystalline powder,smell less
Melting Point	42.0~46.0°C
Specific Rotation	-31°~-39°(CHCl3,C=1)
Identification	The result of HPLC is consisitent to the reference one. The result of IR is consisitent to the reference one.
Related Substances	≤ 0.5%
Total impurity	≤ 1.0%
Single impurity	≤ 0.1%
n-Hexane	≤ 290ppm
Isopropyl ether	≤ 5000ppm
Residual on Ignition	≤0.1%
Sulphate	≤ 0.05%
Heavy Metal	≤ 20ppm
Purity	≤ 99.0% ~ 99.9%

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No Side Effects Orlistat for Weight Loss Steroids Orlipastat USP Standard Images