GMP Manufacturers Ropivacaine Hydrochloride HCl CAS 132112-35-7 White Powder

GMP Manufacturers Ropivacaine Hydrochloride HCl CAS 132112-35-7 White Powder

Product Name: Ropivacaine hydrochloride

Synonyms: S-ROPIVACAINE HCL;(S)-ROPIVACAINE HYDROCHLORIDE;ROPIVACAINE HYDROCHLORIDE MONOHYDRATE;ROPIVCACAINE HYDROCHLORIDE;ROPIVACAINE HCL;(S)-1-propyl-2,6-dimethylanilinoformoxylpiperidine monohydrochloride monohydrate;(S)-1-propyl-2,6-dimethylanilinoformoxylpiperidine,monohydrochloride,monohydrate;(S)-Ropivaxaine hydrochloride
CAS: 132112-35-7
MF: C17H26N2O.ClH.H2O
MW: 328.88
Chemical Properties White Solid
Usage Anesthetic (local)

Ropivacaine Hydrochloride Usage:

1. Contraindications

Ropivacaine is contraindicated for intravenous regional anaesthesia (IVRA). However, new data suggested both ropivacaine (1.2-1.8 mg/kg in 40ml) and levobupivacaine (40 ml of 0.125% solution) be used, because they have less cardiovascular and central nervous system toxicity than racemic bupivacaine.

2. Adverse effects

Adverse drug reactions (ADRs) are rare when it is administered correctly. Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however allergic reactions can rarely occur.

Systemic exposure to excessive quantities of ropivacaine mainly result in central nervous system (CNS) and cardiovascular effects – CNS effects usually occur at lower blood plasma concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations. CNS effects may include CNS excitation (nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, seizures followed by depression (drowsiness, loss of consciousness), respiratory depression and apnea). Cardiovascular effects include hypotension, bradycardia, arrhythmias, and/or cardiac arrest – some of which may be due to hypoxemia secondary to respiratory depression.

3. Treatment of overdose

As for bupivacaine, Celepid, a commonly available intravenous lipid emulsion, can be effective in treating severe cardiotoxicity secondary to local anaesthetic overdose in animal experiments and in humans in a process called lipid rescue.

Company Introduction:

(1) High Quality: HZ is a steroids manufacturer with its own lab and factory.
The purity of our product is tested by our quality department before it is shipped to our clients. Mostly steroids are 99% purity and approved by SGS,CTI and ITS.

(2) Favorable Price: Our price meets international market performance and we give the best doiscounted price for our new customers and promotioned price for our regular customers.

(3) Safe Fast Delivery: After receiving your payment,we will have professional package team to arrange your parcel within 12 hours.We can guarantee every goods can be successfully deliveried

(4) Available Shipment Way: EMS,HongKong Post,DHL,TNT,UPS,FedEx,Registered Mail,Air Express,Sea Vessel etc

(5) After-Sale Service: We can offer you good service after you place an order.At the same time,we can offer you some homebrew recipe to make injection.More service is more available to you.

Quality control:

All compounds are NMR tested at Bruker spectrometer. Spectrum data is available upon request.

Service and Certificate:

Over decades, we have been helping multi-national pharmaceutical companies and other customers to source or develop qualified suppliers in China.
For new suppliers, we evaluate sources and audit the manufacturing sites, and then give customers reports and recommendations. For quality control, we test samples according to customers method of analysis (if available) or according to our understanding, and arrange pre-shipment samples if necessary. If development is needed, our extensive quality control experience and experienced R&D partners enable us to offer effective technical and analytical support.
We also provide regulatory documentation help for manufacturers. Intellectual Property protection rules are always strictly followed in our practice. We pay special attention to guarantee clear communication and prompt problem-solving between customers and manufacturers.

Custom and Manufacture:

Over years, we have developed reliable custom manufacturing supplier base to minimize the risk for on-time delivery and quality. We can offer One-Stop-Solution from lab, kilo-lab, pilot to commercial production. In addition, our expertise can offer you:

Fluorinated aromatic compounds and Pyridine derivatives are our flagship products. With the rapidly growing utilization, functional Fluoride and Pyridine compounds are widely applied in many state-of-the-art technologies, such as brand new drugs. Our production bases locate in the famous Fluorine Chemical Zone in Fuxin City, Liaoning P.R. Normally we keep more than 2000+ products in regular stock, and put 100+ new products to our pipeline every year.

Custom Synthesis:

For any item you are interested in purchasing that is not listed in our catalog, please send detailed information to the sales department to obtain a quote. Helpful information could include CAS#, Structure, Chemical Name, quantity, purity, how soon you need the material, as well as any additional specifications you require. You send this information to us by email. Most of the catalog items are available for immediate delivery. The custom syntheses typically take 4 to 6 weeks, depending on the complexity of the target molecules.

GMP Manufacturers Ropivacaine Hydrochloride HCl CAS 132112-35-7 White Powder Images